Table of Contents
Journal of Radiotherapy
Volume 2014 (2014), Article ID 708317, 6 pages
http://dx.doi.org/10.1155/2014/708317
Research Article

Radiation Therapy Improves Survival Outcome in Pancreatic Adenocarcinoma: Comparison of a 15-Year Institutional Experience at the University of Nebraska Medical Center with SEER Data

1College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7521, USA
2Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, NE 68198-7521, USA

Received 11 September 2013; Accepted 29 October 2013; Published 27 January 2014

Academic Editor: Oliver Micke

Copyright © 2014 Michael J. Baine and Chi Lin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Cancer Facts & Figures, American Cancer Society, Atlanta, Ga, USA, 2013.
  2. K. A. Goodman and C. Hajj, “Role of radiation therapy in the management of pancreatic cancer,” Journal of Surgical Oncology, vol. 107, no. 1, pp. 86–96, 2013. View at Publisher · View at Google Scholar
  3. F. Wang and P. Kumar, “The role of radiotherapy in management of pancreatic cancer,” The Journal of Gastrointestinal Oncology, vol. 2, pp. 157–167, 2011. View at Google Scholar
  4. “Treatment of locally unresectable carcinoma of the pancreas: comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. Gastrointestinal Tumor Study Group,” Journal of the National Cancer Institute, vol. 80, no. 10, pp. 751–755, 1988. View at Scopus
  5. J. H. Klinkenbijl, J. Jeekel, T. Sahmoud et al., “Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: phase III trial of the EORTC Gastrointestinal Tract Cancer Cooperative Group,” Annals of Surgery, vol. 230, no. 6, pp. 776–784, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. M. W. Saif, “Advancements in the management of pancreatic cancer: 2013,” Journal of the Pancreas, vol. 14, no. 2, pp. 112–118, 2013. View at Publisher · View at Google Scholar
  7. D. J. Klaassen, J. M. MacIntyre, G. E. Catton, P. F. Engstrom, and C. G. Moertel, “Treatment of locally unresectable cancer of the stomach and pancreas: a randomized comparison of 5-fluorouracil alone with radiation plus concurrent and maintenance 5-fluorouracil—an Eastern Cooperative Oncology Group study,” Journal of Clinical Oncology, vol. 3, no. 3, pp. 373–378, 1985. View at Google Scholar · View at Scopus
  8. C. J. Yeo, R. A. Abrams, L. B. Grochow et al., “Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival: a prospective, single-institution experience,” Annals of Surgery, vol. 225, no. 5, pp. 621–636, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. J. M. Herman, M. J. Swartz, C. C. Hsu et al., “Analysis of fluorouracil-based adjuvant chemotherapy and radiation after pancreaticoduodenectomy for ductal adenocarcinoma of the pancreas: results of a large, prospectively collected database at the Johns Hopkins Hospital,” Journal of Clinical Oncology, vol. 26, no. 21, pp. 3503–3510, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. C. C. Hsu, J. M. Herman, M. M. Corsini et al., “Adjuvant chemoradiation for pancreatic adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study,” Annals of Surgical Oncology, vol. 17, no. 4, pp. 981–990, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. F. Regine, K. A. Winter, R. A. Abrams et al., “Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial,” The Journal of the American Medical Association, vol. 299, no. 9, pp. 1019–1026, 2008. View at Publisher · View at Google Scholar
  12. B. Chauffert, F. Mornex, F. Bonnetain et al., “Phase III trial comparing intensive induction chemoradiotherapy (60 Gy, infusional 5-FU and intermittent cisplatin) followed by maintenance gemcitabine with gemcitabine alone for locally advanced unresectable pancreatic cancer. Definitive results of the 2000-01 FFCD/SFRO study,” Annals of Oncology, vol. 19, no. 9, pp. 1592–1599, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. N. K. Malik, K. S. May, R. Chandrasekhar et al., “Treatment of locally advanced unresectable pancreatic cancer: a 10-year experience,” The Journal of Gastrointestinal Oncology, vol. 3, no. 4, pp. 326–334, 2012. View at Publisher · View at Google Scholar
  14. K. J. Opfermann, A. E. Wahlquist, E. Garrett-Mayer, R. Shridhar, L. Cannick, and D. T. Marshall, “Adjuvant radiotherapy and lymph node status for pancreatic cancer: results of a study from the Surveillance, Epidemiology, and End Results (SEER) registry data,” American Journal of Clinical Oncology, 2012. View at Publisher · View at Google Scholar
  15. A. Artinyan, M. Hellan, P. Mojica-Manosa et al., “Improved survival with adjuvant external-beam radiation therapy in lymph node-negative pancreatic cancer: a United States population-based assessment,” Cancer, vol. 112, no. 1, pp. 34–42, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. T. P. McDade, J. S. Hill, J. P. Simons et al., “A national propensity-adjusted analysis of adjuvant radiotherapy in the treatment of resected pancreatic adenocarcinoma,” Cancer, vol. 116, no. 13, pp. 3257–3266, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Franko, D. R. Puri, and C. D. Goldman, “Impact of radiation therapy sequence on survival among patients with resected pancreatic head ductal carcinoma,” Annals of Surgical Oncology, vol. 19, no. 1, pp. 26–30, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Hazard, J. D. Tward, A. Szabo, and D. C. Shrieve, “Radiation therapy is associated with improved survival in patients with pancreatic adenocarcinoma: results of a study from the Surveillance, Epidemiology, and End Results (SEER) registry data,” Cancer, vol. 110, no. 10, pp. 2191–2201, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. M. Stessin, J. E. Meyer, and D. L. Sherr, “Neoadjuvant radiation is associated with improved survival in patients with resectable pancreatic cancer: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) registry,” International Journal of Radiation Oncology, Biology, Physics, vol. 72, no. 4, pp. 1128–1133, 2008. View at Publisher · View at Google Scholar · View at Scopus