Role for PKC 𝛿 in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells

Figure 11

Bryostatin-1 protects RS4;11 but not REH cells from fenretinide-induced cell death. Cell death of human leukemia derived REH cells (a) and RS4;11 cells (b) treated with vehicle (0.2% DMSO) or fenretinide (10 $\mu$M 4-HPR) for 24 hours was examined by trypan blue dye exclusion assay. Where appropriate, cells were pretreated for 2 hours with 10 nM Bryostatin-1 (Bryo). Error bars represent the mean $\pm$ S.D. from three separate experiments. Statistically significant differences from cell viability in untreated cells (standard t-test; $P<.05$) are marked by “*”.

(a)

(b)