Role of RNA-Binding Proteins in MAPK Signal Transduction Pathway

Figure 3

Control of ARE-containing mRNA degradation by TTP. Unphosphorylated TTP binds to the ARE and promotes degradation of the mRNAs. MK2 phosphorylates TTP at two serine residues, and this phosphorylation allows binding of 14-3-3 adaptor proteins and stabilization of the ARE-containing target mRNAs, such as TNFα. TTP can also be phosphorylated by p38. Phopshorylation also excludes TTP from stress granules.