Table of Contents
Journal of Signal Transduction
Volume 2011, Article ID 257862, 10 pages
http://dx.doi.org/10.1155/2011/257862
Research Article

Jak2-Independent Activation of Stat3 by Intracellular Angiotensin II in Human Mesangial Cells

Hines VA Medical Center, Hines, IL 60141, USA

Received 1 March 2011; Revised 12 May 2011; Accepted 7 June 2011

Academic Editor: Fred Schaper

Copyright © 2011 Rekha Singh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. J. Leehey, A. K. Singh, and R. Singh, “Angiotensin II and its receptors in the pathogenesis of diabetic nephropathy,” in The Diabetic Kidney, P. Cortes and C. E. Mogensen, Eds., pp. 3–21, Humana Press, New Jersey, NJ, USA, 2006. View at Google Scholar
  2. S. Kagami, W. A. Border, D. E. Miller, and N. A. Noble, “Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells,” Journal of Clinical Investigation, vol. 93, no. 6, pp. 2431–2437, 1994. View at Google Scholar · View at Scopus
  3. R. Singh, N. Alavi, A. K. Singh, and D. J. Leehey, “Role of angiotensin II in glucose-induced inhibition of mesangial matrix degradation,” Diabetes, vol. 48, no. 10, pp. 2066–2073, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. V. Kolm, U. Sauer, B. Olgemoller, and E. Schleicher, “High glucose-induced TGF-b1 regulates mesangial production of heparin sulfate proteoglycan,” American Journal of Physiology, vol. 270, pp. F812–F821, 1996. View at Google Scholar
  5. F. N. Ziyadeh, K. Sharma, M. Ericksen, and G. Wolf, “Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-b,” Journal of Clinical Investigation, vol. 93, no. 2, pp. 536–542, 1994. View at Google Scholar · View at Scopus
  6. E. J. Lewis, L. G. Hunsicker, R. P. Bain, and R. D. Rohde, “The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy,” New England Journal of Medicine, vol. 329, no. 20, pp. 1456–1462, 1993. View at Publisher · View at Google Scholar
  7. S. Andersen, L. Tarnow, P. Rossing, B. V. Hansen, and H. H. Parving, “Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy,” Kidney International, vol. 57, no. 2, pp. 601–606, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Igarashi, A. Hirata, Y. Kadomoto, and M. Tominaga, “Dual blockade of angiotensin II with enalapril and losartan reduces proteinuria in hypertensive patients with type 2 diabetes,” Endocrine Journal, vol. 53, no. 4, pp. 493–501, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. C. Lansang, D. A. Price, L. M. B. Laffel et al., “Renal vascular responses to captopril and candesartan in patients with type 1 diabetes,” Kidney International, vol. 59, no. 4, pp. 1432–1438, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Singh, A. K. Singh, and D. J. Leehey, “A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruli,” American Journal of Physiology, vol. 288, no. 6, pp. F1183–F1190, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Noda, T. Matsuo, H. Nagano-Tsuge et al., “Involvement of angiotensin II in progression of renal injury in rats with genetic non-insulin-dependent diabetes mellitus (Wistar fatty rats),” Japanese Journal of Pharmacology, vol. 85, no. 4, pp. 416–422, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Singh, A. K. Singh, N. Alavi, and D. J. Leehey, “Mechanism of increased angiotensin II formation in glomerular mesangial cells cultured in high glucose,” Journal of the American Society of Nephrology, vol. 14, no. 4, pp. 873–880, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. D. J. Leehey, M. A. Isreb, S. Marcic, A. K. Singh, and R. Singh, “Effect of high glucose on superoxide in human mesangial cells: role of angiotensin II,” Nephron, vol. 100, no. 1, pp. 46–53, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Singh and D. J. Leehey, “Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucose,” Biochemical and Biophysical Research Communications, vol. 357, no. 4, pp. 1040–1045, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. R. Singh, D. Choubey, J. Chen, and D. J. Leehey, “Inhibition of intracellular angiotensin II blocks high glucose effect on mesangial matrix,” Regulatory Peptides, vol. 158, no. 1–3, pp. 103–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. F. L. P. Fierensa, P. M. L. Vanderheyden, C. Roggeman, J. De Backer, T. J. Thekkumkara, and G. Vauquelin, “Tight binding of the angiotensin AT1 receptor antagonist,” Biochemical Pharmacology, vol. 61, no. 10, pp. 1227–1235, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. M. B. Marrero, A. K. Banes-Berceli, D. M. Stern, and D. C. Eaton, “Role of the JAK/STAT signaling pathway in diabetic nephropathy,” American Journal of Physiology, vol. 290, no. 4, pp. F762–F768, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Amiri, S. Shaw, X. Wang et al., “Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose,” Kidney International, vol. 61, no. 5, pp. 1605–1616, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Wang, S. Shaw, F. Amiri, D. C. Eaton, and M. B. Marrero, “Inhibition of the JAK/STAT signaling pathway prevents the high glucose-induced increase in TGF-b1 and fibronectin synthesis in mesangial cells,” Diabetes, vol. 51, no. 12, pp. 3505–3509, 2002. View at Google Scholar · View at Scopus
  20. R. Ardaillou, D. Chansel, C. Chatziantoniou, and J. Dussaule, “Mesangial AT1 receptors: expression, signaling, and regulation,” Journal of the American Society of Nephrology, vol. 10, supplement 1, pp. S40–S46, 1999. View at Google Scholar · View at Scopus
  21. C. D. McWhinney, R. A. Hunt, K. M. Conrad, D. E. Dostal, and K. M. Baker, “The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes,” Journal of Molecular and Cellular Cardiology, vol. 29, no. 9, pp. 2513–2524, 1997. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Chung, E. Uchida, T. C. Grammer, and J. Blenis, “Stat3 serine phosphorylation by ERK-dependent and independent pathways negatively modulates its tyrosine phosphorylation,” Molecular and Cellular Biology, vol. 17, no. 11, pp. 6508–6516, 1997. View at Google Scholar · View at Scopus
  23. M. S. Ali, P. P. Sayeski, L. B. Dirksen, D. J. Hayzer, M. B. Marrero, and K. E. Bernstein, “Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor,” Journal of Biological Chemistry, vol. 272, no. 37, pp. 23382–23388, 1997. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Liang, V. J. Venema, X. Wang, H. Ju, R. C. Venema, and M. B. Marrero, “Regulation of angiotensin II-induced phosphorylation of Stat3 in vascular smooth muscle cells,” Journal of Biological Chemistry, vol. 274, no. 28, pp. 19846–19851, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. R. N. Re and J. L. Cook, “The mitochondrial component of intracrine action,” American Journal of Physiology, vol. 299, no. 3, pp. H577–H583, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Re, “The nature of intracrine peptide hormone action,” Hypertension, vol. 34, no. 4, pp. 534–538, 1999. View at Google Scholar · View at Scopus
  27. J. L. Zhuo, X. C. Li, J. L. Garvin, L. G. Navar, and O. A. Carretero, “Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells,” American Journal of Physiology, vol. 290, no. 6, pp. F1382–F1390, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. K. M. Baker and R. Kumar, “Intracellular angiotensin II induces cell proliferation independent of AT1 receptor,” American Journal of Physiology, vol. 291, no. 5, pp. C995–C1001, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Licea, M. R. Walters, and L. G. Navar, “Renal nuclear angiotensin II receptors in normal and hypertensive rats,” Acta physiologica Hungarica, vol. 89, no. 4, pp. 427–438, 2002. View at Google Scholar · View at Scopus
  30. K. D. Pendergrass, D. B. Averill, C. M. Ferrario, D. I. Diz, and M. C. Chappell, “Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat,” American Journal of Physiology, vol. 290, no. 6, pp. F1497–F1506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. X. C. Li and J. L. Zhuo, “Intracellular ANG II directly induces in vitro transcription of TGF-b1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1 a receptors,” American Journal of Physiology, vol. 294, no. 4, pp. C1034–C1045, 2008. View at Publisher · View at Google Scholar · View at Scopus