Table of Contents
Journal of Signal Transduction
Volume 2011 (2011), Article ID 317852, 10 pages
http://dx.doi.org/10.1155/2011/317852
Review Article

Tyrosine Kinase Signaling in Kidney Glomerular Podocytes

1Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan
2Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
3Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan
4Division of Functional Proteomics, Graduate School of Nanobioscience, Yokohama City University Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Received 21 January 2011; Revised 17 March 2011; Accepted 30 March 2011

Academic Editor: J. Adolfo García-Sáinz

Copyright © 2011 Seisuke Hattori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

During the last decade, several key molecules have been identified as essential components for the filtration barrier function of kidney glomerular podocytes. Mutations in genes encoding these molecules severely impair the podocyte architecture in the affected patients, leading to the development of proteinuria. Extensive investigations have been performed on the function of these molecules, which highlights the importance of tyrosine kinase signaling in the podocytes. An Src family tyrosine kinase, Fyn, plays a major role in this signaling pathway. Here, we review the current understanding of this important signal transduction system and its role in the development and the maintenance of podocytes.