Individual Rac GTPases Mediate Aspects of Prostate Cancer Cell and Bone Marrow Endothelial Cell Interactions
Interaction of prostate cancer cells with bone marrow endothelial cells BMECs was attached to the AFM tip and the unbinding forces of PCa cells measured. PC-3 cells were transfected with siRNAs specific for individual Rac isoforms. Shown are the results from one set of siRNAs. (a) Effect on the frequency of unbinding events and forces (pN) occurring between BMECs and PC-3 cells after depletion of each Rac isoform. (b) Average unbinding force occurring between BMECs and PC-3 cells. The average unbinding force is the physical force required to pull two adhered cells apart. Data are compiled from 3000 data points and are the mean ± S.D. with significance being *.
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