Journal of Signal Transduction / 2011 / Article / Fig 2

Review Article

Podocyte Injury Associated with Mutant α-Actinin-4

Figure 2

Podocyte injury induced by mutant α-actinin-4. (a) Potential actions of α-actinin-4 K256E and other FSGS-associated mutants. (b, c) Potential mechanisms for the cytoskeletal (b) and proteotoxic (c) effects of mutant α-actinin-4 in the podocyte.

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