Podocyte Injury Associated with Mutant α-Actinin-4

Figure 2

Podocyte injury induced by mutant α-actinin-4. (a) Potential actions of α-actinin-4 K256E and other FSGS-associated mutants. (b, c) Potential mechanisms for the cytoskeletal (b) and proteotoxic (c) effects of mutant α-actinin-4 in the podocyte.

(a)

(b)

(c)