Functional Diversity of the Schistosoma mansoni Tyrosine Kinases
Figure 2
Representative sequence domain architectures of some S. mansoni TKs belonging to the receptor and nonreceptor members. Protein family abbreviation is indicated on the left side of each protein architecture (see the list of abbreviations for the respective full names). Protein identifiers (e.g., Smp_125360) shown above each image were retrieved from SchistoDB [14]. Abbreviations followed are: PTK_domain (protein tyrosine kinase catalytic domain), SH2 (Src Homology 2 domain), SH3 (Src Homology 3 domain), PDB (P21-Rho-binding domain), Ank (ankyrin repeat), Recep_L_domain (receptor L domain), Furin-like (furin-like cysteine rich region), ANF_recep (receptor family ligand-binding region), Ephrin_Ibd (ephrin receptor ligand-binding domain), and BTK (Bruton's tyrosine kinase motif). The protein domain architectures were generated using DOG 1.0 [35] based on the domain limits Pfam [25].
