Functional Diversity of the Schistosoma mansoni Tyrosine Kinases

Table 1

Protein tyrosine kinase classification. Tyrosine kinases classified into ePK groups, families, and subfamilies followed the proposed hierarchy described elsewhere [7–9]. RTK: receptor tyrosine kinase. CTK: cytoplasmic tyrosine kinase.

Type	Abbreviation	Family name
RTK	Alk	Anaplastic lymphoma kinase
	Axl	Also known as TAM (Tyro3, Axl, Mer) after the three human members
	CCK4	Colon carcinoma Kinase 4
	DDR	Discoidin domain receptor kinase
	EGFR	Epidermal growth factor receptor
	Eph	Ephrin receptor
	FGFR	Fibroblast growth factor receptor
	InR	Insulin Receptor
	Met	MET or MNNG HOS transforming gene
	MUSK	Muscle-specific kinase
	PDGFR	Platelet-derived growth factor receptor
	Ret	Ret proto-oncogene
	ROR	RAR-related orphan receptor
	Tie	Tyrosine kinase with immunoglobulin-like and EGF-like domains
	VEGFR	Vascular endothelial growth factor receptor
	VKR	Venus flytrap kinase receptor
CTK	Abl	Abelson murine leukemia homolog
	Ack	Activated Cdc42-associated tyrosine kinase
	Csk	Src subgroup kinase which phosphorylates Src
	Fak	Focal adhesion kinase
	Fer	Fps/Fes related
	Jak	Janus kinase
	Lmr	Lemur kinase
	Ryk	Rich protein kinase
	Sev	Named after Drosophila sevenless, a receptor tyrosine kinase involved in eye cell fate determination
	Src	v-Src sarcoma viral oncogene homolog
	Syc	Syc protein
	Tec	Tec protein tyrosine kinase
	Trk	Trk protein kinase