Review Article

Functional Diversity of the Schistosoma mansoni Tyrosine Kinases

Table 2

Distribution of some tyrosine kinase families in S. mansoni, C. elegans, and human. S. mansoni tyrosine kinases were classified according to KinBase [6] by combining sequence similarity searches (HMMs) and phylogenetic analysis [15]. For comparison, occurrence of the ePKs families in C. elegans and human is shown. RTK: receptor tyrosine kinase. CTK: cytoplasmic tyrosine kinase. (See the list of abbreviations for the respective family full name).

TypeFamilyS. mansoniC. elegansH. sapiens

RTKCCK4101
EGFR414
Eph1114
InsR213
Musk101
Ror112
VKR200

CTKAbl212
Ack222
Csk112
Fak102
Fer1372
Ryk111
Sev111
Src6311
SYK202
Tec105
Trk113