Table of Contents
Journal of Signal Transduction
Volume 2011, Article ID 718609, 9 pages
http://dx.doi.org/10.1155/2011/718609
Review Article

Relevance of VEGF and Nephrin Expression in Glomerular Diseases

Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA

Received 16 March 2011; Accepted 25 May 2011

Academic Editor: Mira Krendel

Copyright © 2011 Claudia A. Bertuccio. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The glomerular filtration barrier is affected in a large number of acquired and inherited diseases resulting in extensive leakage of plasma albumin and larger proteins, leading to nephrotic syndrome and end-stage renal disease. Unfortunately, the molecular mechanisms governing the development of the nephrotic syndrome remain poorly understood. Here, I give an overview of recent investigations that have focused on characterizing the interrelationships between the slit diaphragm components and podocytes-secreted VEGF, which have a significant role for maintaining the normal podocyte structure and the integrity of the filtering barrier.