The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis

Table 1

Mammalian MAP kinases.

MAP kinase	Other names	Relevant information	Phosphorylation site motif
ERK1	P44 MAPK	~86% sequence similarity to ERK2, ubiquitously expressed, UO126 sensitive	TEY
ERK2	P42 MAPK	Ubiquitously expressed, UO126 sensitive	TEY
ERK3	P63, ERKα	Yields a single protein of 100 kDa possessing a C-terminal extension	SEG
ERK1b	ERK4	A separate gene	TEY
JNK1	SAPKγ	Several splice variants	TPY
JNK2	SAPKα	Several splice variants	TYP
JNK3	SAPKβ	Several splice variants	TYP
P38α	P38, CSBP, SAPK2, MAPK14	Sensitive to SB203580	TGY
P38β	P38-2, MAPK11	Sensitive to SB203580	TGY
P38γ	ERK6, SAPK3, MAPK12	SB203580 insensitive	TGY
P38δ	SAPK4 or MAPK13	SB203580 insensitive	TGY
Mxi2		A splice form of P38α	TGY
Exip		A splice form of P38α	TGY
ERK5	BMK1	Cell proliferation, differentiation	TEY
ERK7	MAPK15	Cell proliferation	TEY
NLK	Nemo-like kinase	Ortholog of C. elegans LIT-1, relative of Drosophila nemo	TQE
MAK	Male germ cell- associated kinase	Expressed in testicular cells undergoing meiosis	TDY
MRK	MAK-related kinase	Ubiquitous in adult tissues	TDY
MOK		Phorbol ester sensitive	TEY
KKIALRE		Cdc2-related kinase	TDY
KKIAMRE		T, Y mutants activated in cells	TDY