Review Article
Receptor Tyrosine Kinases in Kidney Development
Table 1
Receptor tyrosine kinases associated with aberrant kidney development.
| RTK type | Renal phenotype | References |
| Ret | Renal agenesis | [26] | FGFR2UB-/- | Reduced UB branching and nephron number Defects in stromal patterning | [27] | FGFR2Mes-/- | Supernumerary UBs, duplex ureters, hydroureter renal agenesis | [28] | EGFR | Hypoplastic renal medulla, dilated collecting ducts reduced ability to concentrate urine | [29] | MetUB-/- | Reduced UB branching and nephron number | [30] | VEGFR2 | Stimulates UB branching, nephrogenesis and vasculogenesis | [31–33] | PDGFRα | Decreased number of mesangial cell defective stromal mesenchyme | [34] | PDGFRβ | Lack of mesangial cells and pericytes | [35] |
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RTK: receptor tyrosine kinase, Ret: rearranged during transfection, FGF: fibroblast growth factor, UB: ureteric bud, Mes: mesenchyme, EGF: epidermal growth factor, Met: hepatocyte growth factor receptor, VEGF: vascular endothelial growth factor, PDGF: platelet-derived growth factor.
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