Receptor Tyrosine Kinases in Kidney Development

Table 1

Receptor tyrosine kinases associated with aberrant kidney development.

RTK type	Renal phenotype	References
Ret	Renal agenesis	[26]
FGFR2^UB-/-	Reduced UB branching and nephron number Defects in stromal patterning	[27]
FGFR2^Mes-/-	Supernumerary UBs, duplex ureters, hydroureter renal agenesis	[28]
EGFR	Hypoplastic renal medulla, dilated collecting ducts reduced ability to concentrate urine	[29]
Met^UB-/-	Reduced UB branching and nephron number	[30]
VEGFR2	Stimulates UB branching, nephrogenesis and vasculogenesis	[31–33]
PDGFRα	Decreased number of mesangial cell defective stromal mesenchyme	[34]
PDGFRβ	Lack of mesangial cells and pericytes	[35]

RTK: receptor tyrosine kinase, Ret: rearranged during transfection, FGF: fibroblast growth factor, UB: ureteric bud, Mes: mesenchyme, EGF: epidermal growth factor, Met: hepatocyte growth factor receptor, VEGF: vascular endothelial growth factor, PDGF: platelet-derived growth factor.