Review Article
Receptor Tyrosine Kinases in Kidney Development
Table 2
Ligands of receptor tyrosine kinases with demonstrated functions in kidney organogenesis.
| Ligand | Model | Renal phenotype | References |
| EGF | IMCD3 cells | Induction of cell migration and process formation in vitro | [36] | | UB cells | Induction of branching morphogenesis in vitro | [37] | FGF7 | FGF7-/- | Small kidneys, reduced UB branching and nephron number | [38] | FGF8 | Pax3Cre/FGF loxP/loxP | Small kidneys, reduced number of collecting duct tips lack of progression of nephrogenesis to the S-shaped body stage short tubules | [39] | | BrachyuryCre/FGF loxP/loxP | Small kidneys, reduced UB branching, lack of progression of nephrogenesis to the comma- and S-shaped body stages | [40] | FGF10 | FGF10-/- | Small kidneys, dysplasia of outer medulla | [41] | GDNF | GDNF-/- | Renal agenesis | [42] | HGF | IMCD3 cells | Induction of cell process formation in vitro | [36] | IGF1 | UB cells | Induction of cell process formation in vitro | [43] | PDGF-B | PDGF-B-/- | Lack of mesangial cells and pericytes | [44] | VEGF | Rat metanephric organ culture | Induction of vasculogenesis and tubulogenesis in vitro | [32] | | Mouse metanephric organ culture | Induction of UB branching and nephrons | [31] | | Rat metanephric and isolated intact UB culture | Induction of UB branching | [33] | | NephrinCre/VEGF-AloxP/loxP | Small glomeruli, paucity of glomerular capillary loops effacement of podocyte foot processes | [45] |
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UB: ureteric bud, IMCD3: murine inner medullary collecting duct cells.
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