Figure 1: Gene organisation and domain structure of CISH (a), SOCS2 (b), SOCS5 (c), and other human SOCS molecules (d). The gene organisation is extracted from the publication by Jin et al. [20] except the tetraodon CISH gene that was derived from the cDNA sequence (acc. no. EF195758) and its genome sequence (at the website http://www.genoscope.cns.fr/blat-server/cgi-bin/tetraodon/). Open boxes represent the untranslated regions, whilst grey boxes represent the coding regions, with sizes given above. Dotted lines show the intron positions and sizes. The domain structure was predicted using the SMART program (at the website http://smart.embl-heidelberg.de/).