Figure 3: An unrooted maximum likelihood (ML) phylogenetic tree of the SOCS family members from tetrapods and fish. The tree was constructed based on a multiple alignment of all the known fish SOCS family members and selected molecules from mammals, amphibians, and birds, using the Jones-Thornton-Taylor (JTT) aa matrix and all sites within the MEGA5 program [32]. Node values represent percent bootstrap confidence derived from 2,000 replicates. The molecule and the common species name are followed by the accession number. The new sequences reported in this review are shaded.