Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?

Figure 1

p53 Multifunctional domains. The p53 monomer consists of various multifunctional domains including the N-terminal transactivation domain (residues 1–73), a proline-rich region (residues 63–97), the highly conserved DNA-binding core domain (residues 94–312), a tetramerization domain located within the C-terminus (residues 324–355), and an unstructured basic domain (residues 360–393).