Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-Tumorigenic?

Figure 3

Mechanism involving the p53-MnSOD interaction during the early stage of tumor promotion. Following exposure to a carcinogen the Ras-Rac1-NADPH oxidase pathway is activated, which leads to p53 mitochondrial translocation. Mitochondrial p53 has been shown to interact with MnSOD, resulting in decreased enzymatic activity and promoting oxidative stress propagation contributing to the early stage of skin tumorigenicity. Elevated levels of MnSOD reduced oxidative stress propagation, suppressed p53 mitochondrial translocation, and decreased downstream skin tumor formation. Reduced levels of MnSOD have been shown to contribute to oxidative stress propagation and promote early-stage skin tumorigenicity.