Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells
Figure 1
Differential MAPK pathway-related gene expression in UtLM cells mediated by -estradiol in the presence of scrambled siRNA (siScr) or IGF-IR silencing (siIGF-IR). (a) Heat maps of real-time RT2 Profiler PCR Array of MAPK-related genes. The red areas represent the genes that are upregulated, and the green areas represent the genes that are downregulated by E2 treatment. (b) Plot of fold changes of MAPK-related genes in response to E2 treatment in UtLM cells with siScr or siIGF-IR.
