Table of Contents
Journal of Signal Transduction
Volume 2012 (2012), Article ID 248759, 10 pages
Review Article

RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt

1Département d'Anatomie et Biologie Cellulaire, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
2Pharmacology Department, Weill Cornell Medical College, New York, NY 10065, USA

Received 30 March 2012; Revised 5 July 2012; Accepted 22 July 2012

Academic Editor: Claire Brown

Copyright © 2012 Yannick D. Benoit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Interactions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion structure integrity and are key players in regulating transduction of specific intracellular signals, which in turn regulate the organization of the cell microenvironment and, consequently, cell function. The RGD peptide-dependent integrins represent a key subgroup of ECM receptors involved in the maintenance of epithelial homeostasis. Here we review recent findings on RGD-dependent ECM-integrin interactions and their roles in human intestinal epithelial crypt cells.