RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt

Figure 4

Regulation of the dynamic assembly of fibronectin by ILK. Schematic representation of the proposed mechanism by which ILK regulates FN assembly in HIEC. (a) Following cellular adhesion, the ILK/IPP complex is recruited to focal adhesions providing the link between the actin cytoskeleton and integrin α5β1. IPP recruitment mediates the formation of mature focal adhesions that allow fibronectin deposition into the BM of HIEC. (b) Depletion of ILK in HIEC results in the disruption of the IPP complex which prevents actin cytoskeleton-α5β1 linkage and focal adhesions cannot mature. Consequently, loss of the IPP complex reduces FN deposition and decreases migration of HIEC.