The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries

<table>Treatment-dependent regulation of survivin expression in U87MG (a), U87/EGFR (b), and U87/EGFRvIII (c) glioma cells. Cells were treated with the indicated concentrations of Iressa, mechlorethamine (HN2), Iressa + HN2, ZRBA4 or ZR2003 for 48 h. Cell lysates (40 <i>μ</i>g) were fractionated by SDS-PAGE and probed with antisurvivin (1 : 2000) antibodies (see Materials and methods for details). Blots were subsequently stripped and reprobed for <i>α</i>-actinin (1 : 1500). Major protein bands of 16 (survivin) and 100 kDa (<i>α</i>-actinin) were obtained.</table>

Journal of Signal Transduction

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Figure 10

Figure 10: The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries 

Figure 10 | The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries 