Focal Adhesion Kinases in Adhesion Structures and Disease

Figure 2

Dynamics of podosome organization in osteoclasts. Osteoclasts were generated from mouse bone marrow and plated on FBS-treated coverslips for various times. Cells were fixed and stained with rhodamine phalloidin. Actin patches are found soon after osteoclast attachment. Actin patches then reorganize into small rings and then into a peripheral podosome belt. The podosome belt is stabilized by the microtubule network. Scale bar is 10 μm.