Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

Figure 2

ROS levels control cell fate. Low production of ROS works as trigger of autophagic/mitophagic process, with consequent removal of damaged mitochondria and in turn cellular survival (upper panel). On the other hand, high levels of ROS lead to cell death promoting the apoptotic pathway when prosurvival attempt fails (lower panel).