Journal of Signal Transduction / 2012 / Article / Fig 5

Research Article

Commitment of Satellite Cells Expressing the Calcium Channel α2δ1 Subunit to the Muscle Lineage

Figure 5

Expression of myogenic transcription factors in satellite cells. (a) Expression levels of MyoD and myogenin were measured in the four subpopulations after two days in culture. Cells expressing α2δ1+ had significantly larger expression of myogenin than MyoD, while α2δ1 cells expressed larger levels of MyoD than myogenin. Statistical differences between data points are represented by lines ( ). The asterisks represent significant differences of that value with respect to all other data points. (b) The ratio of myogenin to MyoD was significantly higher in α2δ1+-expressing cells, indicating a more advanced differentiation into myotubes than α2δ1 cells. values ranged from <0.01 to <0.001.

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