Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Figure 2

“Square” action potentials roughly similar to the original APW fail to enable upregulation of Ca_v3.2 by ΔKelch. (a) Original APW waveform was used (left) and square action potential was tested (SQAP). The overlapped signals is shown for comparison. (b) Percentage of increase in calcium influx with the SQAP with respect to control; the magnitude of the changes induced by the original APWs are shown with dotted lines (𝐾=KLHL1;  Δ𝐾=ΔKelch); ^∗𝑃<0.05.

(a)

(b)