Research Article

Elimination of the Actin-Binding Domain in Kelch-Like 1 Protein Induces T-Type Calcium Channel Modulation Only in the Presence of Action Potential Waveforms

Figure 5

Changes in the afterhyperpolarization slope restore the ΔKelch effect, increasing Ca2+ influx through C a v 3.2. (a) SQAP with afterhyperpolarization slopes of 20 mV/ms (blue), 0.75 mV/ms (black), and 0.35 mV/ms (orange). (b) Percentage of increase in calcium influx with the three waveforms with respect to control; the magnitude of the changes induced by the original APWs is shown with dotted lines ( 𝐾 = K L H L 1 ;   Δ 𝐾 = Δ K e l c h ); 𝑃 < 0 . 0 5 .
505346.fig.005a
(a)
505346.fig.005b
(b)