Table of Contents
Journal of Signal Transduction
Volume 2012, Article ID 804801, 7 pages
Research Article

Effects of Somatic Mutations in the C-Terminus of Insulin-Like Growth Factor 1 Receptor on Activity and Signaling

Department of Physiology and Biophysics, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA

Received 7 March 2012; Accepted 28 April 2012

Academic Editor: A. Yoshimura

Copyright © 2012 Barbara P. Craddock and W. Todd Miller. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplemental Figure 1: Purification of the cytoplasmic domains of wild-type IGF1R and the cancer-associated mutants. The proteins were analyzed by SDS-PAGE with Coomassie staining. The arrowhead indicates the position of IGF1R. The lower-molecular weight contaminant is a degradation product [9].

  1. Supplemental Figure