Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?

Figure 4

ROS in the crosstalk between integrins and cadherins. ROS generated by integrin activation may influence cadherin adhesive functions by various mechanisms, including inhibition of PTPs and/or activation of PTKs, RPTKs, and IQGAP acting at adherens junctions, as well as spatiotemporal modulation of the activity of redox-sensitive small GTPases and signaling endosomes.