Table of Contents
Journal of Signal Transduction
Volume 2012, Article ID 956958, 8 pages
Review Article

DNA Methylation, Histone Modifications, and Signal Transduction Pathways: A Close Relationship in Malignant Gliomas Pathophysiology

Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Carretera Madrid-Barcelona Km. 33.6, 28871 Madrid, Spain

Received 13 February 2012; Accepted 19 June 2012

Academic Editor: Laura Cerchia

Copyright © 2012 Raúl Alelú-Paz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Gliomas are the most common type of primary brain tumor. Although tremendous progress has been achieved in the recent years in the diagnosis and treatment, its molecular etiology remains unknown. In this regard, epigenetics represents a new approach to study the mechanisms that control gene expression and function without changing the sequence of the genome. In the present paper we describe the main findings about the alterations of cell signaling pathways in the most aggressive glioma in the adult population, namely, glioblastoma, in which epigenetic mechanisms and the emerging role of cancer stem cell play a crucial function in the development of new biomarkers for its detection and prognosis and the corresponding development of new pharmacological strategies.