Table of Contents
Journal of Signal Transduction
Volume 2014 (2014), Article ID 962962, 16 pages
http://dx.doi.org/10.1155/2014/962962
Review Article

A Network Map of FGF-1/FGFR Signaling System

1Institute of Bioinformatics, International Tech Park, Bangalore 560066, India
2Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605014, India
3Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore 570006, India
4Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 30013, Taiwan
5McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
6Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
7Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
8Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

Received 20 November 2013; Accepted 3 March 2014; Published 16 April 2014

Academic Editor: Shoukat Dedhar

Copyright © 2014 Rajesh Raju et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis. Given the biomedical significance of FGFs and the fact that individual FGFs have different roles in diverse physiological processes, the analysis of signaling pathways induced by the binding of specific FGFs to their cognate receptors demands more focused efforts. Currently, there are no resources in the public domain that facilitate the analysis of signaling pathways induced by individual FGFs in the FGF/FGFR signaling system. Towards this, we have developed a resource of signaling reactions triggered by FGF-1/FGFR system in various cell types/tissues. The pathway data and the reaction map are made available for download in different community standard data exchange formats through NetPath and NetSlim signaling pathway resources.