Phosphatase and Tensin Homologue: Novel Regulation by Developmental Signaling

Figure 1

Protein domains of PTEN. PTEN has five distinct domains, consisting of an N-terminal PIP binding domain, the phosphatase domain responsible for its enzymatic activity and containing acetylation sites responsible for regulating this phosphatase activity, the regulatory C2 domain responsible for its cellular location and protein-protein interactions including those that modify enzyme activity or localization, the less understood C-tail containing phosphorylation sites thought to be critical for PTEN’s stability, and finally the C-terminal PDZ domain.