Table of Contents
Journal of Sexually Transmitted Diseases
Volume 2015, Article ID 791024, 5 pages
Review Article

Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck

1Department of Oral Medicine and Radiology, A B Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte, Mangalore 575018, India
2Department of Ophthalmology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore 575018, India
3Department of Microbiology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore 575018, India

Received 28 May 2015; Accepted 8 September 2015

Academic Editor: Perry Halkitis

Copyright © 2015 Vidya Ajila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Oral cancer is one of the commonest causes for mortality and morbidity with squamous cell carcinoma being the sixth most frequent malignant tumour worldwide. In addition to tobacco and alcohol, human papilloma virus (HPV) is associated with a proportion of head and neck cancers. As in cervical cancers, HPV types 16 and 18 are the cause of malignant transformation. HPV-positive cancers of head and neck have unique characteristics such as occurrence in a younger age group, distinct clinical and molecular features, and better prognosis as compared to HPV-negative carcinomas. They also possess the potential for prevention by using vaccination. The present review describes in detail the salient features of HPV associated oral squamous cell carcinoma (OSCC), its differences from HPV-negative OSCC, diagnostic features, and recent strategies in prevention and management.