Theoretical Investigation of the D83V Mutation within the Myocyte-Specific Enhancer Factor-2 Beta and Its Role in Cancer

Figure 1

A symmetrical MEF2B dimer (shown as a multicolor cartoon) is bound to asymmetrical DNA (indicated in violet). The asymmetry of a complex is further enhanced with binding of a HDAC peptide ligand (indicated in dark blue) to the N-terminal domain of MEF2B. The D83 residue of MEF2B is shown as sticks.