Scale Alpha and Beta of Quantitative Convergence and Chemical Reactivity Analysis in Dual Cholinesterase/Monoamine Oxidase Inhibitors for the Alzheimer Disease Treatment Using Density Functional Theory (DFT)

Figure 1

Conjunctive approach of acetylcholinesterase inhibitor (AChEIs) donepezil (𝟏) with the indolyl propargylamino moiety of the monoamino oxidase (MAO) 𝐴 and 𝐵 inhibitor N-[(5-benzyloxy-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine (𝟐). Forming the IMAO/IAChe hybrids [13].