Table of Contents
Journal of Viruses
Volume 2014, Article ID 691953, 5 pages
Research Article

Hepatitis B Virus Seroprevalence and Serology Patterns in a Cohort of HIV Positive Individuals from Harare, Zimbabwe

1Division of Basic Medical Sciences, National University of Science and Technology, P.O. Box AC939, Ascot, Bulawayo, Zimbabwe
2Department of Medical Microbiology, University of Zimbabwe College of Health Sciences, Mazowe Street, P.O. Box A178, Avondale, Harare, Zimbabwe

Received 19 September 2014; Accepted 4 November 2014; Published 27 November 2014

Academic Editor: Massimo Ciccozzi

Copyright © 2014 Mayibongwe Louis Mzingwane and Tafadzwa Mamvura. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Zimbabwe is highly endemic for hepatitis B virus (HBV) and also has high human immunodeficiency virus (HIV) prevalence rates which may result in HIV/HBV coinfection, and as HIV/HBV coinfection may affect the classical HBV serology patterns and cause interpretation challenges, we assessed the seroprevalence of HBV in HIV positive patients and determined their serology profiles. This was a cross-sectional study on 957 HIV positive specimens from treatment naive patients. HBV serology tests were done using enzyme immunoassays for the detection of HBV markers in human serum or plasma. Hepatitis B surface antigen (HBsAg) prevalence was 17.1% (males 19.0%, females 15.8%). Previous and/or current HBV exposure was evident in 59.8% of the patients and hepatitis B e antigen markers were present in 103 (10.8%) specimens. There was high prevalence of unusual HBV patterns with 14.1% of total specimens showing an anti-HBc alone profile and an additional 4.3% HBsAg positive specimens that were anti-HBc negative.