A Limited Sampling, Simple, and Useful Method for Determination of Glomerular Filtration Rate in Cats by Using a New Accurate HPLC Method to Measure Iohexol Plasmatic Concentrations

Table 2

The mean of bodyweight (BW), plasma urea (PU), plasma creatinine concentration (PCr), 7-point reference clearance of IOX (GFR 7 samples: 5, 30, 60, 120, 240, 360, and 480 minutes), and simplified models clearance of IOX in nonazotaemic and azotaemic cats. ∗Significantly different to nonazotaemic cats at 𝑃<0.05.

Cats	BW (kg)	PU (mmol/L)	PCr (𝜇mol/L)	GFR (mL/min/kg) 7 samples	GFR (mL/min/kg) Model A	GFR (mL/min/kg) Model B	GFR (mL/min/kg) Model C	GFR (mL/min/kg) Model D
Nonazotaemic (𝑛=35)	3.5 (2.0–5.0)	15.29 (6.92–24.13)	106 (78–140)	3.40 (1.21–8.62)	3.32 (1.52–6.80)	3.28 (1.64–6.62)	3.08 (1.40–6.87)	3.43 (1.51–8.30)
Azotaemic (𝑛=15)	3.36 (2.0–5.5)	19.78 (16.63–31.38)	160 (143–209)*	2.38 (1.36–3.47)*	2.11 (1.25–2.99)*	2.57 (1.49–4.17)*	2.28 (1.35–3.66)*	2.26 (1.45–3.81)*