Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats

Table 1

Mean (±SE) kinetic parameters of cefquinome following repeated intramuscular injections of 2 mg/kg b.wt. once daily for three consecutive days in sheep and goats.

Parameter	Unit	Sheep			Goat
		1st day	2nd day	3rd day	1st day	2nd day	3rd day
A	μg·mL^−1	1.75±0.10	1.72±0.06	1.70±0.12	1.73±0.08	1.75±0.09	1.56±0.13
𝐾ab	h^−1	0.91±0.036	0.85±0.06	0.97±0.02	0.93±0.015	0.83±0.035	1.03±0.02
𝑇0.5(ab)	h	0.76±0.036	0.82±0.02	0.73±0.02	0.73±0.016	0.82±0.03	0.67±0.02
𝐵	μg·mL^−1	2.37±0.14	2.58±0.10	2.82±0.21	2.43±0.09	2.71±0.08	2.74±0.13
𝐾el	h^−1	0.074±0.002	0.057±0.004	0.05±0.005	0.068±0.003	0.057±0.002	0.044±0.002
𝑇0.5(el)	h	9.03±0.89	11.35±1.40	14.01±0.99	10.14±1.42	11.57±1.28	15.71±1.52
𝐶max	μg·mL^−1	1.80±0.09	2.03±0.14	2.30±0.10	1.88±0.10	2.15±0.09	2.38±0.08
𝑇max	h	2.61±0.11	2.77±0.21	2.70±0.15	2.62±0.09	2.88±0.19	2.62±0.13
AUC(0-inf)	μg·h·mL^−1	29.96±1.20	40.61±3.16	54.98±4.21	31.11±1.05	45.22±2.08	61.20±3.44
MRT	h	14.23±1.10	16.98±1.75	20.60±1.31	15.16±1.44	16.97±0.88	23.06±2.78
IBD	h	27.91±3.53	—	—	28.82±4.88	—	—

A: zero-time intercept of distribution phase; 𝐾_ab: first-order absorption rate constant; 𝑇_0.5(ab)": absorption half-life; B: zero-time intercept of elimination phase; 𝐾_el: first-order elimination rate constant; 𝑇_0.5(el): elimination half-life; 𝐶_max: maximum serum concentration; 𝑇_max: time to peak serum concentration; AUC_(0-inf): area under serum concentration-time curve; MRT: mean residence time; IBD: interval between doses.