Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats

Table 4

Signs of nausea-related behavior in single- and repeat-dose trials.

Group; 4 ♀, 4 ♀	Observation of biting or self-licking
	Day
	1	2	3	4	5	6	7	8	9	10	11	12
Single dose
0.0
1.3		1 ♀	1 ♀
3.9	1 ♂	1 ♂; 1 ♀	1 ♂; 2 ♀
6.5			1 ♂; 1 ♀
Repeat doses				2nd dose				3rd dose
0.0							1 ♂			2 ♂
1.3	1 ♂	1 ♂	1 ♂	2 ♂; 1 ♀	2 ♂; 1 ♀	2 ♂	2 ♂; 1 ♀	1 ♂; 1 ♀	1 ♂	2 ♂; 1 ♀	2 ♂
3.9	1 ♀	1 ♀	1 ♀		1 ♀	4 ♂		1 ♂	1 ♂
6.5					1 ♀		1 ♂; 1 ♀		2 ♂; 1 ♀
Cumulative %	5	8	25	9	16	19	19	9	16	13	6

No observation.