Subcutaneous Implants of a Cholesterol-Triglyceride-Buprenorphine Suspension in Rats

Table 5

Mean Body Weight Gains (BWG) for male and female rats in repeat dose trial.

Dose; mg/kg	BWG; Day 0–4	BWG; Day 4–6	BWG; Day 6–8	BWG; Day 8–12	BWG; Day 0–12
Male
Control
Mean	10.9	4.2	−4.1	10.9	22.0
SD	1.5	1.8	6.1	0.9	6.1
1.3
Mean	2.5	6.9	−1.3	11.9	20.1
SD	1.5	2.5	3.9	5.6	7.3
3.9
Mean	0.3	7.1	−1.1	13.2	19.6
SD	2.4	1.4	2.5	2.0	3.0
6.5
Mean	−0.7	5.6	−2.7	8.6	11.0
SD	1.5	1.9	4.2	3.9	7.5
Female
Control
Mean	2.1	2.2	−1.2	6.4	9.6
SD	2.1	2.4	3.0	1.2	2.0
1.3
Mean	−1.9	2.0	−3.4	6.7	3.4
SD	0.3	0.9	3.5	1.4	5.1
3.9
Mean	−3.2	3.8	−2.7	6.7	4.6
SD	1.5	2.6	1.2	5.4	6.3
6.5
Mean	−1.5	3.4	−1.8	7.0	7.0
SD	3.5	1.9	2.7	5.8	6.2