Table of Contents
Lung Cancer International
Volume 2011 (2011), Article ID 152125, 4 pages
http://dx.doi.org/10.4061/2011/152125
Research Article

Prognostic Factors in Advanced Non-Small-Cell Lung Cancer Patients: Patient Characteristics and Type of Chemotherapy

Clinical Oncology Department, King Hussein Cancer Center, Queen Rania Al-Abdullah Street, Al-Jubeiha, Amman 11941, Jordan

Received 29 September 2010; Accepted 24 November 2010

Academic Editor: Kaoru Kubota

Copyright © 2011 Salah Abbasi and Ahmed Badheeb. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Eleven prognostic factors were retrospectively analyzed in 270 newly diagnosed patients with advanced non-small-cell lung cancer including age, sex, performance status, histology, stage, smoking status, hemoglobin level, forced expiratory volume in one second (FEV1), weight loss >5% in 3 months preceding therapy, number of involved organs, and type of first-line chemotherapy. Response rate was 35.6%, and median survival was 8.2 months (95% CI, 7.8 to 8.7) for the whole group. Age ≤60 years ( 𝑃 = . 0 1 6 ), F E V 1 2 L ( 𝑃 = . 0 3 ), and the use of platinum/docetaxel ( 𝑃 < . 0 0 0 1 ) were significantly associated with an improved survival. Histology did not affect outcome in the absence of targeted therapies.