Table of Contents
Lung Cancer International
Volume 2014, Article ID 810786, 6 pages
Research Article

Analysis of Expression of Vascular Endothelial Growth Factor A and Hypoxia Inducible Factor-1alpha in Patients Operated on Stage I Non-Small-Cell Lung Cancer

1Thoracic Surgery, University General Hospital of Albacete, 37 Hermanos Falcó Street, 02006 Albacete, Spain
2Thoracic Surgery, University General Hospital of Valencia and Surgery Department of the School of Medicine and Odontology, University of Valencia, 15 Blasco Ibáñez Avenue, 46010 Valencia, Spain
3Thoracic Surgery, University General Hospital of Valencia, Tres Creus Avenue, 46014 Valencia, Spain

Received 10 October 2013; Revised 15 December 2013; Accepted 26 December 2013; Published 10 February 2014

Academic Editor: Akira Iyoda

Copyright © 2014 Antonio Francisco Honguero Martínez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Recent studies show that expression of hypoxia inducible factor-1alpha (HIF-1α) favours expression of vascular endothelial growth factor A (VEGF-A), and these biomarkers are linked to cellular proliferation, angiogenesis, and metastasis in different cancers. We analyze expression of HIF-1α and VEGF-A to clinicopathologic features and survival of patients operated on stage I non-small-cell lung cancer. Methodology. Prospective study of 52 patients operated on with stage I. Expression of VEGF-A and HIF-1α was performed through real-time quantitative polymerase chain reaction (qRT-PCR). Results. Mean age was 64.7 and 86.5% of patients were male. Stage IA represented 23.1% and stage IB 76.9%. Histology classification was 42.3% adenocarcinoma, 34.6% squamous cell carcinoma, and 23.1% others. Median survival was 81.0 months and 5-year survival 67.2%. There was correlation between HIF-1α and VEGF-A ( ). Patients with overexpression of HIF-1α had a tendency to better survival with marginal statistical significance ( ). Patients with overexpression of VEGF-A had worse survival, but not statistically significant ( ). Conclusion. The present study revealed that VEGF-A showed correlation with HIF-1α. HIF-1α had a tendency to protective effect with a value close to statistical significance. VEGF-A showed a contrary effect but without statistical significance.