Lung Cancer International / 2015 / Article / Tab 2

Research Article

Usefulness of Ki-67, Mitoses, and Tumor Size for Predicting Metastasis in Carcinoid Tumors of the Lung: A Study of 48 Cases at a Tertiary Care Centre in Canada

Table 2

Relationship between various clinical and pathologic factors and metastasis.

MetastasisSensitivitySpecificityOR
Absent ()Present () (%) (%) (95% CI)

Carcinoid type
 Typicalγ34357.182.96.480.039
 Atypical74(1.18, 35.58)
Size, cm
 <3γ29271.470.76.040.080
 ≥3125(1.03, 35.54)
Mitosis
 <2.00γ36357.187.89.600.017
 ≥2.0054(1.64, 56.09)
Ki67 (MCM)
 <0.50γ130100.031.70.166
 ≥0.50287
Ki67 (CIAM)
 <0.50γ21185.751.20.160.106
 ≥0.50206(0.02, 1.44)
Mitosis ≥2 and Ki67 (CIAM) ≥0.50
 Noγ38442.992.79.50 0.033
 Yes33(1.42, 63.72)
Size ≥3 and Ki67 (CIAM) ≥0.50
 Noγ34357.182.96.480.039
 Yes74(1.18, 35.58)
Mitosis ≥2 and size ≥3
 Noγ39442.995.114.620.018
 Yes23(1.86, 115.19)

MCM: manual conventional method; CIAM: computer image analysis method; OR: odd ratio; CI: confidence interval.
γThe reference category for calculation of sensitivity, specificity, and odd ratios.
ΨStatistical comparisons made using Fisher’s exact two-tailed test.

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