Usefulness of Ki-67, Mitoses, and Tumor Size for Predicting Metastasis in Carcinoid Tumors of the Lung: A Study of 48 Cases at a Tertiary Care Centre in Canada

Table 4

A summary of select reported Ki-67 labeling indices in lung carcinoid tumors.

Studies	Number of cases	% of Ki-67 positive cells, mean (range)		Counting method
		TC	AC
Costes et al. 1995 [12]	47	0.45 (0–3.04)	2.43 (0–6.05)	CIAM
Arbiser et al. 2001 [14]	10	1	9	MCM
Igarashi et al. 2004 [16]	18	1.3 (0.3–2.3)	8.6 (0.2–17)	MCM
Pelosi et al. 2005 [15]	7	0.5 (0-1)	7.2 (1–17)	NS
Walts et al. 2012 [19]	101	3.7	18.8	CIAM
Zahel et al. 2012 [21]	200	1.8	3.7	MCM
Rindi et al. 2014 [20]	197	<4	4–<25	MCM, AACAM, and CAMM
Present case	48	0.72	0.95	MCM and CIAM

CIAM indicates computer image analysis method; MCM: manual conventional method; NS: not specified; AACAM: Aperio automated computer assisted method; CAMM: computer assisted manual method; TC: typical carcinoid; AC: atypical carcinoid.