Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia

Figure 1

The inactivated Wnt pathway. Fzd: frizzled receptor, LPR5/LPR5: lipoprotein receptor-related protein 5/6, CKIα: casein kinase I alpha; GSK3β: glycogen synthase kinase 3 beta, β-TrCP: β-transducin repeat-containing protein, DNA: deoxyribonucleic acid, TCF: T-cell factor, and LEF: lymphoid enhancer factor.