Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State
Figure 1
Hypercalcemia in ATL is associated with metastatic calcification. (a)–(d): Metastatic calcification is seen in the pulmonary alveolar septa of the lungs ((a) magnification, ×400), renal tubules of kidneys ((b) magnification, ×200), myocardium ((c) magnification, ×100), and Disses’s space, hepatic cell membrane, and central vein wall ((d) magnification, ×200). von Kossa’s staining for calcium. (e) Osteoclasts are found in the osseous tissue, and infiltration of numerous leukemic lymphoma cells in the bone marrow of the vertebra. Osteoclasts are multinucleated giant cells. Arrows: typical osteoclasts. Hematoxylin and eosin staining. Magnification, ×400. (f) Immunohistochemistry for PTHrP in leukemic lymphoma cells in ATL. PTHrP-positive cells are stained brown. This case was lymphoma type. The large cells were ATL cells, which were infiltrated in normal lymph nodes. ATL cells produce PTHrP, on the other hand, surrounding normal lymphocytes did not produce PTHrP. Magnification, ×400.
