Table of Contents
Leukemia Research and Treatment
Volume 2012, Article ID 150651, 4 pages
http://dx.doi.org/10.1155/2012/150651
Research Article

Identification of a Novel P190-Derived Breakpoint Peptide Suitable for Peptide Vaccine Therapeutic Approach in Ph+ Acute Lymphoblastic Leukemia Patients

1Department of Hematology, University of Siena, 53100 Siena, Italy
2Department of Hematology, University of Florence, 50121 Florence, Italy
3Department of Hematology, University of Pisa, 56126 Pisa, Italy

Received 30 September 2011; Accepted 30 November 2011

Academic Editor: Tiribelli Mario

Copyright © 2012 Micaela Ippoliti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Kurzrock, H. M. Kantarjian, B. J. Druker, and M. Talpaz, “Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics,” Annals of Internal Medicine, vol. 138, no. 10, pp. 819–830, 2003. View at Google Scholar
  2. H. J. Lee, J. E. Thompson, E. S. Wang, and M. Wetzler, “Philadelphia chromosome-positive acute lymphoblastic leukemia,” Cancer, vol. 117, no. 8, pp. 1583–1594, 2011. View at Publisher · View at Google Scholar · View at PubMed
  3. P. P. Piccaluga, G. Martinelli, M. Rondoni, G. Visani, and M. Baccarani, “Advances and potential treatment for Philadelphia chromosome-positive adult acute lymphoid leukaemia,” Expert Opinion on Biological Therapy, vol. 6, no. 10, pp. 1011–1022, 2006. View at Publisher · View at Google Scholar · View at PubMed
  4. G. G. Laport, J. C. Alvarnas, J. M. Palmer et al., “Long-term remission of Philadelphia chromosome-positive acute ymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen,” Blood, vol. 112, no. 3, pp. 903–909, 2008. View at Publisher · View at Google Scholar · View at PubMed
  5. R. Foà, A. Vitale, A. Guarini et al., “Dasatinib as front line treatment of adult Ph+ acute lymphoblastic leukemia (ALL) patients. Final results of the GIMEMA LAL1205 study,” Blood, vol. 112, artilce 305, 2008. View at Google Scholar
  6. G. Riva, M. Luppi, P. Barozzi et al., “Emergence of BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term imatinib mesylate treatment,” Blood, vol. 115, no. 8, pp. 1512–1518, 2010. View at Publisher · View at Google Scholar · View at PubMed
  7. M. Bocchia, S. Gentili, E. Abruzzese et al., “Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial,” The Lancet, vol. 365, no. 9460, pp. 657–662, 2005. View at Publisher · View at Google Scholar · View at PubMed
  8. M. Bocchia, M. Tassi, M. Ippoliti et al., “CMLVAX100 peptide vaccinations induce peptide specific “cytotoxic“ CD4+ T cells (CD4+CTLs) in chronic myeloid leukemia patients: new insights about peptide vaccine-mediated antitumor response,” Blood, vol. 112, article 3209, 2008. View at Google Scholar
  9. H.-G. Rammensee, J. Bachmann, N. P. N. Emmerich, O. A. Bachor, and S. Stevanović, “SYFPEITHI: database for MHC ligands and peptide motifs,” Immunogenetics, vol. 50, no. 3-4, pp. 213–219, 1999. View at Google Scholar