PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells
Figure 12
PKCδ is involved in regulation of translational initiation by eIF2α through PKR axis in AML cells. ATRA and ATO inhibit translation initiation by inducing inactivation (phosphorylation at Ser-51) of eIF2α. Suppression of translation initiation is also regulated by other mediators, including induction of translational suppressors (PDCD4 and DAP5) and inhibition of 4E-BP1 [32–34]. The eIF2α kinases other than PKR, such as GCN2 and PERK, are not involved in regulation of eIF2α during ATRA-induced differentiation. eIF2α is involved in regulation of ATRA-regulated cellular proteins in cell cycle arrest (), proliferation (c-myc), survival (p70S6K), and apoptosis (DAP5/p97) and differentiation (TG2).
