Table of Contents
Leukemia Research and Treatment
Volume 2012, Article ID 692348, 6 pages
http://dx.doi.org/10.1155/2012/692348
Clinical Study

Influence of IL10 (G1082A) and TNFα (G308A) Polymorphisms on the Survival of Pediatric Patients with ALL

1Biological Sciences Institute, Pediatric Hematology Oncology Center (CEONHPE/UPE), Avenida Agamenon Magalhães, Bairro de Santo Amaro, 50100-010 Recife, PE, Brazil
2Biological Sciences Institute, University of Pernambuco (UPE), Avenida Agamenon Magalhães, Bairro de Santo Amaro, 50100-010 Recife, PE, Brazil

Received 18 July 2012; Revised 2 September 2012; Accepted 4 September 2012

Academic Editor: Daniela Cilloni

Copyright © 2012 Dayse Maria Vasconcelos de Deus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Interleukin 10 (IL10) is a pleiotropic cytokine that stimulates various hematopoietic cells. The tumor necrosis factor alpha (TNFα) is a cytokine that may influence the transcriptional activity induced by glucocorticoids. This study examined the impact of TNFα (G308A) and IL10 (G1082A) polymorphisms at promoter regions in relation to the overall survival of 105 children years) with acute lymphoblastic leukemia (ALL) for a period of 126 months, treated according to the protocol GBTLI99. The G1082A and G308A polymorphisms were identified by allele-specific PCR and PCR-RFLP, respectively. Patients with IL10AA genotype had a higher death ratio (44%, . Patients with both IL10AA and TNFAA genotypes showed the worst survival when compared with the IL10GG and TNFGA genotypes ( . The results of this study revealed a lower survival among patients with IL10AA genotype and the concomitant occurrence of IL10AA and TNFAA genotypes.